منابع مشابه
Platelet microRNAs: Novy Mir* or mired in human complexity?
A side from their established role in initiating the vascular occlusive events that culminate in myocardial infarction and stroke, platelets are increasingly appreciated for their relevance to inflammation and carcinogenesis. An overview of randomized trials of antiplatelet drugs, mostly aspirin, indicates that they reduce the secondary incidence of important vascular events by ≈20%, 1 and prov...
متن کاملmiR-25 in heart failure.
1 showed miR-25 to reduce levels of rco/endoplasmic reticulum calcium-ATPase (SERCA) 2a during heart failure, whereas therapeutic inhibition of this microRNA (miRNA) was able to reverse pre-established heart failure in a mouse model of pressure overload. Although these data suggest that miR-25 might be a drug target for the treatment of heart failure, further in vivo analysis is required before...
متن کاملIs population genetics mired in the past?
In a recent TREE perspective, Bossart and Prowell1 concluded that researchers estimating population structure used antiquated methods, and failed to acknowledge and test underlying model assumptions. We found these conclusions surprisingly pessimistic and decided to examine 67 papers on population structure from Evolution and Molecular Ecology (1997). Although many studies in Evolution were bas...
متن کاملmiR-25, integrin and cancer invasiveness
Prostate cancer is the most common cancer amongst men worldwide and major cause of cancer death. Current treatments of primary prostate tumors are initially effective, however, 25% of the patients develop metastatic disease. Once the cancer has acquired resistance to Androgen Deprivation Therapy, Castration Resistant Prostate Cancer (CRPC) occurs. At this stage, highly aggressive prostate cance...
متن کاملThe Three Paralogous MicroRNA Clusters in Development and Disease, miR-17-92, miR-106a-363, and miR-106b-25
MicroRNAs (miRNAs) form a class of noncoding RNA genes whose products are small single-stranded RNAs that are involved in the regulation of translation and degradation of mRNAs. There is a fine balance between deregulation of normal developmental programs and tumor genesis. An increasing body of evidence suggests that altered expression of miRNAs is entailed in the pathogenesis of human cancers...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science-Business eXchange
سال: 2014
ISSN: 1945-3477
DOI: 10.1038/scibx.2014.450